Postdoctoral Research Associate Heinzen Lab Position Available In Orange, North Carolina
Tallo's Job Summary: The Heinzen Lab at the University of North Carolina at Chapel Hill is seeking Postdoctoral Research Associates to study molecular mechanisms of genetic epilepsies. Candidates will work in a highly interdisciplinary environment, utilizing cutting-edge technologies to identify disease mechanisms and drug targets. The role involves developing neuronal models, conducting experiments, and contributing to drug discovery initiatives. Research experience with human induced pluripotent stem cell models is preferred.
Job Description
Vacancy ID:
PDS003793
Position Summary/Description:
The Heinzen laboratory in the Division of Pharmacotherapy and Experimental Therapeutics, in collaboration with the Eshelman Institute for Innovation, in the Eshelman School of Pharmacy at the University of North Carolina at Chapel Hill is looking to immediately fill multiple postdoctoral fellowship positions to study molecular mechanisms across multiple types of genetic epilepsies to identify convergent disease mechanisms and drug targets. The successful candidates will be part of a highly interdisciplinary environment to develop induced pluripotent stem cell derived neuronal models of genetic epilepsies and apply cutting-edge technologies including electrophysiology, single-cell RNAseq, chromatin conformation capture technique, optogenetics, genetic encoded biosensors of neurotransmission, and live cell imaging, to study cellular and molecular signatures associated genetic epilepsies. Well-defined cellular and molecular signatures will be fed into the drug discovery pipeline and/or subjected to CRISPR -screens to identify druggable genetic modifiers as part of the Drug Discovery Initiative led by the Eshelman Institute of Innovation. The ultimate goal is for postdoctoral fellows to develop specialized skill sets to drive independent research programs that can launch independent research careers
Education and Experience:
The projects will involve a significant amount of laboratory bench work. Research experience with human induced pluripotent stem cell models preferred but not required.
