Staff Engineer, Modeling Position Available In Suffolk, Massachusetts

Job Description:

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OBJECTIVE

SyntheticMolecule Process Development (SMPD) is responsible for thedevelopment of robust and cost-effective processes for themanufacture of new small molecule pharmaceuticals, along withmethods for achieving and controlling high standards of purity andquality. The Staff Engineer

• Process Modeling will join a dynamicand innovative team of engineers and scientists within SMPD’sProcess Engineering & Technology Group.

The successful candidatewill have a strong background in chemical reaction engineering andwill tackle challenging problems in chemical reactions byleveraging expertise in reaction kinetics, transport phenomena,mathematical modeling, and reactor design. Additionally, the StaffEngineer will be involved in developing scale-up and scale-downmodels for studying unit operations using both first principle anddata-based models. The role includes the application of processanalytical technologies (PAT) in combination with mathematicalmodels (both mechanistic and statistical) to enhance processunderstanding and enable data-rich experimentation. Theseapproaches will drive the design, optimization, scale-up, andtroubleshooting of synthesis processes, ensuring robustpharmaceutical manufacturing through digital and in-silicomethodologies.

ACCOUNTABILITIES

Contributes to the design,development, optimization, and scale-up of manufacturing processesfor synthetic molecule drug substances using process modeling andsimulation principles. Utilizes advanced process modeling tools anddigital twin functionalities, implementing model-based design ofexperiments for process characterization and risk assessment.

Develops experimental designs and workflows for model development,validation, and verification. Collaborates with cross-functionaland external partners to develop and deploy digital twins of unitoperations. Partners with Automation, Manufacturing, ProcessEngineers, and PAT experts to develop modeling and simulation(M&S) solutions that can be deployed across the globalorganization for in-silico process design, development, andoptimization. Recommends, justifies and implements in silico toolsand an ” in-silico first” approach to process developmentResponsible for authoring relevant sections of regulatorydocuments, validation plans, reports and peer reviewed manuscripts.

Proactively analyze technical issues and coordinate potentialresolutions with project team members based on model and simulationpredictions.

EDUCATION, EXPERIENCE AND SKILLS

Education andExperience:

Required:

Bachelor’s degree in Chemical Engineering ora related pharmaceutical science with 5 years of relevant industryexperience. Master’s degree in Chemical Engineering or a relatedpharmaceutical science with 3 years of relevant industryexperience. Ph.D. in Chemical Engineering or a relatedpharmaceutical science with 0 years of relevant industryexperience. Strong knowledge and understanding of chemical reactionengineering and catalysis, with proven ability to demonstrateskills in these fields. Strong knowledge and understanding oftransport phenomena and thermodynamics. Experience withcommercially available reaction kinetic modeling software such asReactionLab, Dynochem, gPROMS and COMSOL. Experience withcommercially available software for computational fluid dynamics(CFD) modeling such as Ansys, Star CCM, MStar CFD. Proficient incommunicating and data collection from systems such as sensors,controllers, and industrial systems. Experience with Matlab,Python, R, SQL, and good coding practices.

Preferred:

Experiencewith common statistical methods, basic data science principles, andAI/ML methodologies. Hands-on experience in wet lab processdevelopment. Experience in multivariate analysis and PrincipalComponent Analysis (PCA). Understanding of synthetic moleculeprocess development activities. Understanding of current GoodManufacturing Practices (cGMP).

Knowledge and Skills:

Analyticaland Problem Solving Skills

• Able to troubleshoot critical issuesor problems, and determine causes and possible solutions TeamworkAbility to work well in highly cross functional team environmentand across global line functions. Communication Skills
• Able toexpresses one’s self clearly and concisely within team; documentsissues and/or concerns concisely with colleagues; adjustscommunication style as appropriate for the audience; timely andeffectively communicates issues to supervisor; technical writingskills to support authorship of internal technical documentsOrganization
• Exercises good time management and prioritizationskills and is able to successfully manage multiple taskssimultaneously Knowledge Sharing
• Ability to captureorganizational knowledge; improve solutions, processes, anddeliverables through use of information; improve informationcapital by contributing experience, theories, deliverables, andmodels for others to use Resource Management
• Ability to manageone’s time within individual, departmental, and corporate goals andtimelines; management of internal and external resources (vendors)External Involvement
• Demonstrated involvement in professionalcommunity evidenced by presentation of scientific posters orlectures at professional conferences or events Technical
• Subjectmatter expertise and knowledge of applicable process modeling andsimulation tools Takeda Compensation and Benefits Summary Weunderstand compensation is an important factor as you consider thenext step in your career.

We are committed to equitable pay for allemployees, and we strive to be more transparent with our paypractices.

For Location:

Boston, MA U.S.

Base Salary Range:

$111,800.00

• $175,670.

00 The estimated salary range reflects ananticipated range for this position. The actual base salary offeredmay depend on a variety of factors, including the qualifications ofthe individual applicant for the position, years of relevantexperience, specific and unique skills, level of educationattained, certifications or other professional licenses held, andthe location in which the applicant lives and/or from which theywill be performing the job.

The actual base salary offered will bein accordance with state or local minimum wage requirements for thejob location. U.S. based employees may be eligible for short-termand/or long-termincentives. U.S.based employees may be eligible toparticipate in medical, dental, vision insurance, a 401(k) plan andcompany match, short-term and long-term disability coverage, basiclife insurance, a tuition reimbursement program, paid volunteertime off, company holidays, and well-being benefits, among others.

U.S.based employees are also eligible to receive, per calendaryear, up to 80 hours of sick time, and new hires are eligible toaccrue up to 120 hours of paid vacation. EEO Statement Takeda isproud in its commitment to creating a diverse workforce andproviding equal employment opportunities to all employees andapplicants for employment without regard to race, color, religion,sex, sexual orientation, gender identity, gender expression,parental status, national origin, age, disability, citizenshipstatus, genetic information or characteristics, marital status,status as a Vietnam era veteran, special disabled veteran, or otherprotected veteran in accordance with applicable federal, state andlocal laws, and any other characteristic protected by law.

Locations Boston, MA Worker Type Employee Worker Sub-Type RegularTime Type Full time Job Exempt Yes It is unlawful in Massachusettsto require or administer a lie detector test as a condition ofemployment or continued employment. An employer who violates thislaw shall be subject to criminal penalties and civil liability.